CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection

Figure 4 Decreased intestinal IFN-γ production in CD2^-/- mice upon Toxoplasma gondii infection. Production of IFN-γ by lymphocytes and concentration in sera obtained from CD2^-/- or WT mice infected with the ME49 strain of T. gondii. Sera (A) and supernatants of stimulated mLN lymphocytes (B) of CD2^-/- mice contain significantly less IFN-γ than appropriate probes of WT mice (P = 0.009, P = 0.039). Supernatants of stimulated splenocytes (C) of CD2^-/- mice produce significantly more IFN-γ than appropriate cells of WT mice (P = 0.021).