CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection

Figure 2 CD2 deficiency improves ileal Th1 immunopathy after Toxoplasma gondii infection with less necrosis compared to WT mice (P = 0. 002). The histology of the ileum is shown at 7 d after infection. While CD2^-/- mice show a nearly normal histological appearance of the ileum (A), the ileum of WT mice (B) show disintegration of epithelial layer, cellular shedding into the lumen and massive crypt destruction. The box blot on the (C) summarizes the examination of the ilea of 8 CD2^-/- and 8 WT mice giving the median, upper and lower quartile, maximum and minimum.