Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease

Table 4 Estimated haplotype frequency distributions of CLOCK gene SNPs in the control group and in NAFLD patients

Haplotype	Control group	NAFLD patients	OR (95% CI)	Empiric P
	(n = 128)	(n = 272)		level
GACCGA	0.275	0.433	1.82 (1.22-2.70)	0.00562
CAGACG	0.363	0.309	0.89 (0.54-1.49)	0.316
CGCAGG	0.160	0.147	0.84 (0.46-1.53)	0.737
GGCCGA	0.118	0.088	0.73 (0.35-1.54)	0.371
CGCACG	0.084	0.024	0.27 (0.09-0.83)	0.00902

NAFLD: Non-alcoholic fatty liver disease. Haplotypes are composed by variants of rs1554483, rs11932595, rs4580704, rs6843722, rs6850524 and 4864548 in that order. n: Number of chromosomes examined. P value for overall comparison by χ² test.