Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease

Table 3 Association of single-tagSNP and multi-marker tag SNP tests (haplotypes) in CLOCK with NAFLD

Single tagSNP	Associated	Frequency	OR (95% CI)	Empiric
	allele			P value
rs1554483	G	0.491	1.51 (0.93-2.45)	0.0599
rs11932595	A	0.712	1.65 (1.10-2.47)	0.0449
rs4580704	C	0.688	1.03 (0.68-1.55)	0.99
rs6843722	C	0.476	1.70 (1.05-2.76)	0.0239
rs6850524	G	0.643	1.40 (0.85-2.29)	0.1458
rs4864548	A	0.478	1.54 (0.95-2.50)	0.0779
Multi-marker tagSNP test	Associated haplotype	Frequency	OR (95% CI)	Empiric P value
rs11932595, rs6850524	AC	0.315	0.88 (1.55-1.41)	0.91
	GC	0.039	0.32 (0.10-0.94)	0.099
rs4580704, rs4864548	CA	0.477	1.55 (0.99-2.44)	0.1066
	GG	0.307	0.90 (0.56-1.46)	0.8764
	CG	0.212	0.62 (0.37-1.07)	0.119
rs4580704, rs6843722	CA	0.213	0.58 (0.34-0.98)	0.0792
rs4580704, rs6850524	GC	0.300	0.90 (0.56-1.47)	0.939
rs6850524, rs4864548	GG	0.171	0.81 (0.46-1.45)	0.806

Empiric P values were obtained by adjusting nominal P values for multiple testing by permutation test.