Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

Figure 1 Mean log₁₀ changes in serum hepatitis B virus (HBV) DNA levels after administration of lamivudine (dashed line) and adefovir (continuous line). Mean (± SD) changes from baseline in serum HBV DNA concentrations were evaluated using real time PCR assays (lower limit of detection, 366 copies/mL). ^aP < 0.05. HBV: hepatitis B virus; LMV: lamivudine; ADV: adefovir dipivoxil.