Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

Table 2 Types of lamivudine (LMV)-resistant mutations in 40¹ patients in whom analysis of LMV-resistant mutation was performed

Types of LMV-resistant mutations	Patients n (%)	HBV DNA level2
M204I	8 (20.0)	7.5 ± 0.7
M204V	1 (2.5)	8.03
M204I + L180M	19 (47.5)	7.5 ± 0.9
M204V + L180M	12 (30.0)	7.8 ± 0.5

¹In the remaining four patients, LMV-resistant mutations were diagnosed clinically by the reappearance of hepatitis B virus (HBV) DNA after HBV DNA negativization (determined by hybridization assay).

²Serum HBV DNA levels were measured by real time polymerase chain reaction (PCR), with a lower limit of 366 copies/mL and subjected to log₁₀ transformation.

³HBV DNA level of mutation M204V was expressed only as a mean value because n = 1. LMV: lamivudine; HBV: hepatitis B virus.