Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure

Table 2 Hepatocyte apoptosis index and number of cells expressing Cyt-C and caspase-3 (mean ± SD, number/HP)

Groups	Number	Apoptosis index	Cyt-C	Caspase-3
Control group	5	0	1.67 ± 0.90	3.87 ± 2.42
Model group	5	33.2 ± 4.37	59.47 ± 3.79	85.6 ± 6.25
After therapy 6 h	5	32.3 ± 4.7	58.47 ± 3.83	84.00 ± 5.54
After therapy 1 d	5	26.6 ± 4.67b	46.33 ± 5.51b	72.3 ± 5.21b
After therapy 3 d	5	19.9 ± 3.54b	31.53 ± 2.83b	56.13 ± 6.87b
After therapy 5 d	5	11.1 ± 2.77b	25.47 ± 3.94b	34.1 ± 4.87b
After therapy 7 d	5	5 ± 2.83b	15.00 ± 4.11b	17 ± 4.5b

^bP < 0.01 vs the model group. Apoptosis index: t_6h = 0.56, t_1d = 4.10, t_3d = 8.26, t_5d = 13.73, t_7d = 17.52. Cyt-c: t_6h = 0.72, t_1d = 9.45, t_3d = 20.1, t_5d = 24.46, t_7d = 31.99. Caspase-3: t_6h = 1.09, t_1d = 12.2, t_3d = 26.9, t_5d = 47.2, t_7d = 62.9.