Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma

Table 1 Clinical profile of 151 HCC patients with extrahepatic metastases at the initial diagnosis of extrahepatic metastases

Age (yr)	64 (21-82)
Sex (male/female)	117/34
Etiology (HBV/HCV/HBV + HCV/others)	33/89/5/24
PS (0/1/2/3/4)	90/43/9/6/3
Intrahepatic tumor stage (T0/1/2/3/4)	11/4/13/43/80
Intrahepatic main tumor size (mm)	48 (0-160)
Intrahepatic tumor volume (< 50%/≥ 50%)	103/48
Intrahepatic tumor morphology (nodular type/non nodular type/no intrahepatic HCC)	83/57/11
Grade of portal vein invasion (Vp 0/1/2/3/4)	74/0/26/28/23
Child-Pugh grade (A/B/C)	88/48/15
AFP (ng/mL)	741.8 (< 5-861 600)
DCP (mAU/mL)	1300 (< 10-391 400)
Site of extrahepatic metastases, n (%)
Lung	63 (42)
Lymph nodes	60 (40)
Bone	51 (34)
Adrenal	16 (11)
Peritoneum	1 (0.7)
Pancreas	1 (0.7)
Nasal passages	1 (0.7)

Data are expressed as medians and ranges unless indicated otherwise. HBV: hepatitis B virus; HCV: hepatitis C virus; PS: Eastern Cooperative Oncology Group performance status; T0: no intrahepatic HCC; Portal invasion assessed Vp1: tumor thrombus in a third or more of the peripheral branches; Vp2: in the second branch; Vp3: in the first branch; Vp4: in the trunk; AFP: alpha-fetoprotein; DCP: Des-γ-carboxy prothrombin.