Vascular damage and anti-angiogenic effects of tumor vessel-targeted adenovirus-mediated herpes simplex virus thymidine kinase gene

Figure 4 Microvessel density of tumors detected by anti-CD31 immunochemistry staining (S-P, × 100). A: MVD (CD31 staining, × 200) of hepatoma treated with Ad group (II); (30.6 ± 7.8); B: MVD (CD31 staining, × 200) of hepatoma treated with AdCMV-TK group (III); (27.6 ± 7.1); C: MVD (CD31 staining, × 200) of hepatoma treated with AdKDR-TK group (IV); (10.7 ± 4.1).