E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance

doi:10.3748/wjg.v13.i29.3925

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Aug 7, 2007 (publication date) through Nov 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Aug 7, 2007; 13(29): 3925-3931
Published online Aug 7, 2007. doi: 10.3748/wjg.v13.i29.3925

Table 3 Results of survival analysis in EBV-GC and non EBV-GC cases

	Non EBV-GCs			EBV GCs
	Death¹/Total (%)	HR²	95% CI²	Death¹/Total (%)	HR²	95% CI²
Depth
m, sm	6/29 (21)	1	Referent	3/13 (23)	1	Referent
pm	3/13 (23)	0.76	0.19-3.07	2/8 (25)	1.64	0.23-11.9
s, ss, se	37/58 (64)	2.03	0.74-5.53	18/28 (64)	6.03	1.39-26.2
		P = 0.112			P = 0.005
Lymph node metastasis
0	10/51 (20)	1	Referent	13/32 (41)	1	Referent
1	16/26 (62)	3.55	1.44-8.77	4/9 (44)	2.13	0.57-7.94
2+	20/23 (87)	6.83	2.75-17.0	6/8 (75)	7.77	1.93-31.3
		P < 0.001			P = 0.004
Lauren classification
Diffuse	14/30 (47)	1	Referent	6/20 (30)	1	Referent
Intestinal	32/70 (46)	1.10	0.55-2.02	17/29 (59)	9.47	2.67-33.6
		P = 0.865			P < 0.001
p53
Negative	21/52 (40)	1	Referent	13/26 (50)	1	Referent
Positive	25/48 (52)	1.60	0.87-2.91	10/23 (43)	1.29	0.50-3.30
		P = 0.127			P = 0.595
E-cadherin in membrane
Preserved	9/28 (32)	1	Referent	6/12 (50)	1	Referent
Lost	37/72 (51)	1.50	0.70-3.22	17/37 (46)	0.73	0.25-2.12
		P = 0.276			P = 0.568
E-cadherin in nuclei and/or cytoplasm
Negative	30/62 (48)	1	Referent	12/26 (46)	1	Referent
Positive	16/38 (42)	0.56	0.30-1.06	11/23 (48)	1.37	0.56-3.34
		P = 0.071			P = 0.481
Beta-catenin in membrane
Preserved	28/64 (44)	1	Referent	19/43 (44)	1	Referent
Lost	18/36 (50)	1.10	0.57-2.11	4/6 (67)	1.39	0.42-4.60
		P = 0.778			P = 0.601
Beta-catenin in nuclei and/or cytoplasm
Negative	41/89 (20)	1	Referent	18/37 (49)	1	Referent
Positive	5/11 (45)	0.81	0.31-2.09	5/12 (42)	0.32	0.11-0.93
		P = 0.654			P = 0.028

¹Gastric-cancer related death.

²HRs, 95% CIs, and P values were obtained by Cox proportional hazard models. Age, depth, lymph node metastasis, Lauren classification, and p53 expression were included in the models as covariates. The coefficient of age was 0.029 (SE = 0.018, P = 0.114) in non EBV-GCs, and 0.076 (SE = 0.026, P = 0.004) in EBV-GCs. m: mucosa, sm: submucosa, pm: propia muscularis, s: serosa, ss: subserosa, se: serosa exposed.

Citation: Koriyama C, Akiba S, Itoh T, Sueyoshi K, Minakami Y, Corvalan A, Yonezawa S, Eizuru Y. E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance. World J Gastroenterol 2007; 13(29): 3925-3931
URL: https://www.wjgnet.com/1007-9327/full/v13/i29/3925.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i29.3925