Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer

Table 2 LN metastasis in relation to immunohistochemical molecular markers in submucosal CRC

Immunohistochemical	markers	n	LN positive(%)	P value
MVD	Low	88	2 (2.3)	< 0.0001
	High	126	26 (20.6)
LVD	Low	109	5 (3.8)	0.0002
	High	105	23 (18.9)
Ki-67 LI	Low	90	7 (7.8)	0.0499
	High	124	21 (16.9)
MUC1	Negative	108	5 (4.6)	0.0002
	Positive	106	23 (21.7)
Cathepsin D	Negative	85	3 (3.5)	0.0008
	Positive	129	25 (19.4)
MMP-7	Negative	103	8 (7.8)	0.0263
	Positive	111	20 (18.0)
Total			214	28 (13.1)

LN: lymph node metastasis; CRC: Colorectal cancer; MVD: microvessel density; LVD: lymphatic vessel density; MUC1: mucin 1; LI: labeling index; MMP-7: matrix metalloproteinase-7.