Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: In vivo and in vitro studies

Figure 3 Percentage aggregation (mean ± SD) obtained in HCV-positive patients and controls, in basal conditions and after incubation with GSNO. Compared with controls % maximal aggregation induced by ADP was significantly increased in CH patients. Moreover, the collagen addition induced a significant increase in % maximal aggregation in the platelets from CH patients. After incubation with GSNO, % maximal aggregation induced by ADP was significantly reduced in both groups, but the reduction was much more evident in the CH patients, while % maximal aggregation induced by ADP was not changed by the addition of GSNO in control group and was significant reduced in CH patients. C: controls; CH: chronic hepatitis; GSNO: nitrosoglutathione. ^aP < 0.05, ^bP < 0.01 vs ADP; ^dP < 0.01 vs collagen; ^cP < 0.05 vs ADP; ^fP < 0.01 vs collagen.