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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2007; 13(27): 3714-3720
Published online Jul 21, 2007. doi: 10.3748/wjg.v13.i27.3714
Published online Jul 21, 2007. doi: 10.3748/wjg.v13.i27.3714
Table 1 Tests for K-ras, p53 and p16 mutations, and LOH at chromosome 9p (site of p16 gene) and LOH at chromosome 18q (site of DPC4 gene) n (%)
| Chronicpanceratitis | Pancreaticcancer | Total | Sensitivity(95% CI) | Specificity(95% CI) | P | Youden'sindex | ||
| K-ras | Negative | 20 (100) | 24 (29.6) | 44 (43.6) | 70% | 100% | < 0.001 | 70% |
| Positive | 0 (0) | 57 (70.4) | 57 (56.4) | (60%-80%) | ||||
| Total | 20 (100) | 81 (100) | 101 (100) | |||||
| p53 | Negative | 18 (90) | 62 (76.5) | 80 (79.2) | 24% | 90% | 0.18 (NS) | 14% |
| Positive | 2 (10) | 19 (23.5) | 21 (20.8) | (14%-34%) | (85%-95%) | |||
| Total | 20 (100) | 81 (100) | 101 (100) | |||||
| p16 | Negative | 20 (100) | 70 (87.5) | 90 (90) | 13% | 100% | 0.096 (NS) | 13% |
| Positive | 0 (0) | 10 (12.5) | 10 (10) | (7%-19%) | ||||
| Total | 20 (100) | 80 (100) | 100 (100) | |||||
| LOH 9p | Negative | 9 (64.3) | 8 (15.4) | 17 (25.8) | 85% | 64% | < 0.001 | 49% |
| Positive | 5 (35.7) | 44 (84.6) | 49 (74.2) | (75%-95%) | (53%-75%) | |||
| Total | 14 (100) | 52 (100) | 66 (100) | |||||
| LOH 18q | Negative | 8 (57.1) | 11 (22.4) | 19 (30.2) | 78% | 57% | < 0.05 | 35% |
| Positive | 6 (42.9) | 38 (77.6) | 44 (69.8) | (67%-89%) | (45%-69%) | |||
| Total | 14 (100) | 49 (100) | 63 (100) |
- Citation: Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M. Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. World J Gastroenterol 2007; 13(27): 3714-3720
- URL: https://www.wjgnet.com/1007-9327/full/v13/i27/3714.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i27.3714