Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: Studies in vitro and in conditionally transgenic mice

Figure 1 Western blotting for protein extracted from transfected HeLa cells and representative transgenic mice liver. A: two months old mice; B: the faint 21-KD-core band (line 4) in six months old mice. Lanes 1 and 2: proteins from transfected HeLa cells without and with the administration of doxycycline which served as positive and negative controls. Lanes 3 and 4: proteins from the transgenic mice fed with and without doxycycline chow, respectively; C: The quantitative comparison of the blotting. Black bar, female 2 mo old DTM liver protein (1.26 ± 0.08); white bar: female 6 mo old DTM liver protein (0.34 ± 0.05), P = 0.002 between black and white bars (mean ± SD, n = 3).