Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells

Figure 5 Glucose change of STZ-induced diabetic rats after D-MSCs transplantation via portal vein. Glucose levels in the D-MSCs implanted rats began to decrease at d 6 following transplantation, kept below 15 mmol/L during d 12 to d 16, and then elevated again after d 20. In contrast, glucose levels in islets implanted rats decreased at d 2, kept below 15mmol/L during d 4 to d 8, and then elevated again after d 10. Glucose levels in the pre-induced BM-MSCs implanted rats remained elevated. ^aP < 0.05, ^bP < 0.01 vs pre-induced BM-MSCs implanted rats.