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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 21, 2007; 13(23): 3237-3244
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3237
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3237
Table 2 Results of fibrosis, oxidative stress parameters, activated HSC counts and apoptotic cells in groups 1-4
| Spontaneous recovery(n = 15) | Peginterferon-alpha(n = 15) | Taurine(n = 15) | Peginterferon-alpha plusTaurine (n = 15) | |
| Histological score | 5 (5-6) | 3 (2-4) | 2 (1-3) | 3 (2-4) |
| Percentage fibrosis (%) | 14.3 ± 0.8 | 7.9 ± 0.5 | 7.9 ± 0.6 | 6.1 ± 0.3 |
| Hydroxyproline (μg/g wet weight) | 1.03 ± 0.07 | 0.58 ± 0.04 | 0.64 ± 0.03 | 0.32 ± 0.04 |
| MDA (nmol/g tissue) | 47.8 ± 1.0 | 43.3 ± 1.8 | 20.2 ± 0.8 | 18.4 ± 0.6 |
| GPx (U/g tissue) | 128 ± 3 | 168 ± 6 | 271 ± 13 | 270 ± 11 |
| SOD (U/g tissue) | 343 ± 5 | 385 ± 8 | 644 ± 14 | 619 ± 19 |
| alpha-SMA (+) cell count | 120.0 ± 9.4 | 59.6 ± 2.7 | 46.7 ± 3.5 | 32.6 ± 3.0 |
| Apoptotic hepatocyte count | 19.1 ± 1.0 | 31.3 ± 2.6 | 34.8 ± 3.9 | 43.9 ± 4.0 |
| Apoptotic activated HSC count | 4.6 ± 0.5 | 14.1 ± 1.5 | 11.0 ± 0.8 | 21.5 ± 2.0 |
- Citation: Tasci I, Mas MR, Vural SA, Deveci S, Comert B, Alcigir G, Mas N, Akay C, Bozdayi M, Yurdaydin C, Bozkaya H, Uzunalimoglu O, Isik AT, Said HM. Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis. World J Gastroenterol 2007; 13(23): 3237-3244
- URL: https://www.wjgnet.com/1007-9327/full/v13/i23/3237.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i23.3237