Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis

doi:10.3748/wjg.v13.i23.3189

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jun 21, 2007; 13(23): 3189-3198
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3189

Table 4 Correlation between muc2, cdx2, Li-cadherin, Ki-67 index and clinicopathologic features n (%)

		MUC2 expression			CDX2 expression			Li-cadherin expression			Ki-67 index
Factors	Cases	MUC2-(n = 34)	MUC2+(n = 32)	P	CDX2-(n = 52)	CDX2+(n = 14)	P	Li-cad-(n = 42)	Li-cad+(n = 24)	P	≤ 25%(n = 40)	> 25%(n = 26)	P
Gender
Male	32	17 (50.0)	15 (46.9)	> 0.05	23 (44.2)	9 (64.3)	> 0.05	18 (42.9)	14 (58.3)	> 0.05	18 (45.0)	14 (53.8)	> 0.05
Female	34	17 (50.0)	17 (53.1)		29 (55.8)	5 (35.7)		24 (57.1)	10 (41.7)		22 (55.0)	12 (46.2)
Age (yr)
Mean ± SE	66	50.9 ± 2.2	56.0 ± 2.2	> 0.05¹	53.5 ± 1.9	52.9 ± 3.1	> 0.05¹	51.9 ± 3.0	54.6 ± 2.6	> 0.05¹	53.9 ± 2.2	51.0 ± 2.3	> 0.05¹
Tumor diameter
< 5.0 cm	32	23 (67.6)	9 (28.1)	0.001	30 (57.7)	2 (14.3)	0.004	24 (57.1)	8 (33.3)	> 0.05	24 (60.0)	8 (30.8)	0.02
≥ 5.0 cm	34	11 (32.4)	23 (71.9)		22 (42.3)	12 (85.7)		18 (42.9)	16 (66.7)		16 (40.0)	18 (69.2)
Depth of wall invasion
T₁	13	11 (32.4)	2 (6.3)	0.008²	13 (25.0)	0	> 0.05	10 (23.8)	3 (12.5)	> 0.05	11 (27.5)	2 (7.7)	0.048²
T₂	22	10 (29.4)	12 (37.5)		16 (30.8)	6 (42.9)		15 (35.7)	7 (29.2)		14 (35.0)	8 (30.8)
T₃	22	10 (29.4)	12 (37.5)		15 (28.8)	7 (50.0)		11 (26.2)	11 (45.8)		10 (25.0)	12 (46.2)
T₄	9	3 (8.8)	6 (18.8)		8 (15.4)	1 (7.1)		6 (14.3)	3 (12.5)		5 (12.5)	4 (15.4)
Lymph node metastasis
LN (–)	29	21 (61.8)	8 (25.0)	0.003	25 (48.1)	4 (28.6)	> 0.05	20 (47.6)	9 (37.5)	> 0.05	22 (55.0)	7 (26.9)	0.025
LN (+)	37	13 (38.2)	24 (75.0)		27 (51.9)	10 (71.4)		22 (52.4)	15 (62.5)		18 (45.0)	19 (70.1)
Distant metastasis
M₀	60	32 (94.1)	28 (87.5)	> 0.05	48 (92.3)	12 (85.7)	> 0.05	39 (92.9)	21 (87.5)	> 0.05	36 (90.0)	24 (92.3)	> 0.05
M₁	6	2 (5.9)	4 (12.5)		4 (7.7)	2 (14.3)		3 (7.1)	3 (12.5)		4 (10.0)	2 (7.7)
Vascular invasion
V (–)	40	27 (79.4)	13 (40.6)	0.001	34 (65.4)	6 (42.9)	> 0.05	31 (73.8)	9 (37.5)	0.004	28 (70.0)	12 (46.2)	> 0.05
V (+)	26	7 (20.6)	19 (59.4)		18 (34.6)	8 (57.1)		11 (26.2)	15 (62.5)		12 (30.0)	14 (53.8)
TNM stage
I+ II	32	22 (64.7)	10 (31.2)	0.007	27 (51.9)	5 (35.7)	> 0.05	21 (50.0)	11 (45.8)	> 0.05	24 (60.0)	8 (30.8)	0.02
III + IV	34	12 (35.3)	22 (68.8)		25 (48.1)	9 (64.3)		21 (50.0)	13 (54.2)		16 (40.0)	18 (69.2)

¹t test;

²T1 vs T2 + T3 + T4.

Citation: Tian MM, Zhao AL, Li ZW, Li JY. Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis. World J Gastroenterol 2007; 13(23): 3189-3198
URL: https://www.wjgnet.com/1007-9327/full/v13/i23/3189.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i23.3189