Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis

Table 3 Different expression patterns of phenotype markers and Ki67 and β-catenin expression in gastric SRC carcinoma

					β-catenin	Plasma/Nucleusβ-cateninexpression
Phenotype of gastricSRC carcinomas	Number ofpositive GPM	Number ofpositive IPM	Cases	Ki67 index> 25%	membraneexpression
G type			17	2 (11.8%)	11 (64.7%)	2 (11.8%)
G1	1	0	5	0	3 (60.0%)	0
G2	2	0	9	2 (22.2%)	6 (66.7%)	1 (11.1%)
G3	3	0	3	0	2 (66.7%)	1 (33.3%)
I type			10	5 (50.0%)	1 (10.0%)b	4 (40.0%)
I1	0	1	4	1 (25.0%)	0	1 (25.0%)
I2	0	2	3	3 (100%)	0	2 (66.7%)
I3	0	3	3	1 (33.3%)	1 (33.3%)	1 (33.3%)
GI type			31	15 (48.4%)a	12 (36.4%)	14 (45.2%)a
GI1	1	1	6	3 (50.0%)	2 (33.3%)	3 (50.0%)
GI2	1	2	3	1 (33.3%)	1 (33.3%)	1 (33.3%)
GI3	1	3	1	0	0	1 (100%)
GI4	2	1	6	3 (50.0%)	3 (50.0%)	3 (50.0%)
GI5	2	2	5	4 (80.0%)	4 (80.0%)	2 (40.0%)
GI6	2	3	5	2 (40.0%)	1 (20.0%)	1 (20.0%)
GI7	2	4	1	0	0	1 (100%)
GI8	3	1	2	1 (50.0%)	1 (50.0%)	1 (50.0%)
GI9	3	2	2	1 (50.0%)	0	1 (50.0%)
U type	0	0	8	3 (37.5%)	4 (50.0%)	3 (37.5%)

GPM: Gastric phenotype marker. IPM: Intestinal phenotype marker.

^aP < 0.05,

^bP < 0.05 vs G type.