CagA+ H pylori infection is associated with polarization of T helper cell immune responses in gastric carcinogenesis

Figure 5 Representatives of immunohistochemistry staining for IFN-γ and IL-4 in gastric biopsies of CagA+ H. pylori (A), CagA- H pylori (B) and those without H pylori infected patients(C) with normal gastric mucosa or with different gastric pathologies (DAB, ×200, Arrowhead shows the representative positive cells, which are stained brown). A₁, B₁, C₁, D₁, E₁ and F₁ represent IFN-γ expression in normal mucosa (NM), chronic gastritis (CG), gastric atrophy (GA), intestinal metaplasia (IM) and gastric cancer (GC), respectively, and A₂, B₂, C₂, D₂, E₂ and F₂ represent IL-4 expression in NM, CG,GA,IM, DP AND GC, respectively. A: The rates of IFN-γ+ cells are great in the CG, GA, and IM groups relative to the DP and GC groups. Additionally, the rates of IL-4+ cells are less in the NC and CG groups, but increased along the progression; B: The rates of IFN-γ+ cells and IL-4+ cells were constant in all the groups, and IFN-γ expression with “++” was dominant, while IL-4 expression with “+” was in the majority of all the groups; C: The rates of IFN-γ+ cells and IL-4+ cells were constant in all the groups, and IFN-γ expression with “++” was dominant, while IL-4 expression with “+” was in the majority of all the groups.