Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease

Table 2 TIMP-1 genotype distribution at SNP + 372 C/T in CD patients compared to controls

Protein	Genotype	CD (% of patients)	Controls (% of individuals)	P1	Allele	CD (% of total)	Controls (% of total)	P-value
TIMP-1, ♂	T	67.9	51.6	0.055	T	67.9	51.6	0.055
	C	32.1	48.4		C	32.1	48.4
TIMP-1, ♀	TT	39	23.8	0.018	T	56.5	50.7	0.238
	TC	35.1	53.6		C	43.5	49.3
	CC	26	22.5

♂: n = 53/54 vs 93/96; ♀: n = 77/80 vs 151/152 successful genotype determinations, respectively. ¹P-value, Chi-Square test.