5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro

Figure 1 Dose-dependent inhibitory effect of 5-ASA and nimesulide on proliferation of HT-29 colon carcinoma cells. The cells were pretreated with different doses of 5-ASA or nimesulide respectively (10, 50, 100, 500, 1000 μmol/L) for 48 h, then dye uptake was measured at 490 nm using an ELISA reader. Data were expressed as mean ± SE of five independent samples. Compared with the control group, the inhibitory rate was markedly increased in a dose-dependent manner (P < 0.05).