Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients

Table 1 Histological and virological characteristics of 71 patients with chronic HBV infection mean ± SD

Parameter	Total (n = 71)	HBeAg positive (n = 54)	HBeAg seroconversion (n = 17)
Knodell score: pretreatment	8.2 ± 4.1	8.4 ± 4.1	7.1 ± 4.2
post-treatment	5.8 ± 3.4a	6.0 ± 3.6	5.1 ± 3.1a
Intrahepatic HBV DNA (log10): pretreatment	6.1 ± 1.0	6.3 ± 0.8	5.6 ± 1.2
post-treatment	4.9 ± 1.4a	5.1 ± 1.5	4.1 ± 0.8a
Serum HBV DNA (log10): pretreatment	7.7 ± 1.1	7.9 ± 0.9	7.5 ± 1.0
post-treatment	4.0 ± 1.3a	4.4 ± 1.4a	3.0 ± 0.2a
ALT (nkat/L): pretreatmen	3390 ± 2321	3206 ± 2354	3841 ± 2371
post-treatment	868 ± 885a	9853 ± 985	618 ± 659a

^aP < 0.05 vs pretreatment.