Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection

Table 2 ALT level before and after treatment in each group mean ± SD

Group	n	ALT (U/ L)
		Beforeinjection	One week after injection	Three weeks after injection
A (Control)	12	43.56 ± 7.24	45.33 ± 8.29	75.33 ± 12.51
B (Nano HAP)	11	39.29 ± 6.52	42.73 ± 10.05d	59.55 ± 15.40ad
C (Nano HAP)	12	40.38 ± 6.88	43.75 ± 6.30d	62.00 ± 14.49ad
D (5-FU)	11	42.70 ± 7.08	74.64 ± 15.55b	99.73 ± 14.70b
E (5-FU + HAP)	12	42.86 ± 6.79	59.67 ± 12.66bc	86.42 ± 11.54ac

^aP < 0.05,

^bP < 0.01, vs A group;

^cP < 0.05,

^dP < 0.01, vs D group.