Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection

Table 1 Change of average weight of animals in each group mean ± SD

Group	n	Weight (kg)
		Before injection	One week after injection	Three weeks after injection
A (Control)	12	2.73 ± 0.21	2.67 ± 0.21	2.32 ± 0.14
B (HAP)	11	2.66 ± 0.15	2.59 ± 0.14	2.46 ± 0.19ad
C (HAP)	12	2.70 ± 0.16	2.61 ± 0.14	2.52 ± 0.12ad
D (5-FU)	11	2.70 ± 0.17	2.47 ± 0.17a	1.95 ± 0.14b
E (5-FU + HAP)	12	2.78 ± 0.19	2.60 ± 0.18	2.23 ± 0.22d

^aP < 0.05,

^bP < 0.01, vs group A;

^dP < 0.01, vs group D.