Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment

Figure 1 Northern blot analysis of ISG expression and its modulation by lamivudine in HepG2 and HepG2. 2.15 cells. HepG2 and HepG2.2.15 cells were cultured in the absence or presence of 2 μmol/L of lamivudine for 10 d. Then, the cells were stimulated with 100 or 1000 IU/mL of IFN-α for 6 h. Total cellular RNAs were isolated for Northern blotting hybridization. Lam: lamivudine.