Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment

Table 2 Suppression of ISG induction in HepG2.2.15 cells, effect of lamivudine treatment

Gene	Acc. No.	HepG2	2.2.15	HepG2/lam	2.2.15/lam
I complete inhibition
MxA	M33882	5.9	0.6	4.0	0.8
cig5	AF026941	2.2	0.9	2.1	1.2
II partial inhibition
IFITM3	X57352	3.4	1.6	3.4	1.8
IFITM2	X57351	2.7	1.6	2.2	1.8
III reversible inhibition
IFI 6-16	BC015603	7.9	4.4	7.2	6.5
IFITM1	M24594	4.9	2.5	4.8	4.6
IV no inhibition
2-5OAS	D00068	3.8	4.0	4.4	5.8
MxB	M30818	1.4	2.0	1.4	1.9
Caspase 7	U67319	2.3	2.4	2.2	2.1
IFI 17	J04164	3.3	2.9	2.8	2.7
IFI 27	X67325	1.9	2.1	1.8	2.2
IFI T4	U72882	2.7	1.9	2.6	1.8
RING4	X57522	2.4	2.3	2.5	3.5

Cells were stimulated with 100 U/mL IFN-α for 6 h with or without pre-treatment with 2 μmol/L lamivudine for 10 d. Then, RNA was isolated and assayed by cDNA macroarray. Data are shown as fold induction compared to the untreated control. Lam: Lamivudine.