Maintenance of radiation-induced intestinal fibrosis: Cellular and molecular features

Figure 6 A: Fibrosis is a progressive pathology that involves sequential activation of chronic molecular loops. Gradation of fibrosis severity correlates with a decreased number of resident cells and decreased the potential of recovery; B: Impact of prophylactic treatment on the development of fibrosis: early inhibition of one or few molecular loops would help to preserve the regenerative potential of the tissue; C: Impact of curative treatment on fibrosis maintenance: inhibition of one or few chronic loop would help to preserve the regenerative potential of the tissue thus leading to tissue recovery.