Effects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in rats

doi:10.3748/wjg.v13.i18.2596

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May 14, 2007 (publication date) through Nov 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2007; 13(18): 2596-2599
Published online May 14, 2007. doi: 10.3748/wjg.v13.i18.2596

Table 1 Effects of 5-FU and 5-FU + G-CSF administration on peritoneal defense mechanisms and systemic WBC counts. Figures are expressed as median (range)

	Control (n: 10)	5-FU (n: 10)	5-FU + G-CSF (n: 10)
Bactericidal activity of peritoneal fluid MIC₉₀ (bacteria/mL)	17.90 (14.1-24.6)	9.40 (6.2-13.8)^a	19.20 (14.3-26.8)
Phagocytic activity of PMNL	56.3 (48.3-62.6)	36 (25-51.6)^a	43.5 (37-58.6)
Cell counts in peritoneal fluid	2000 (1500-2400)	950 (600-1200)^a	1380 (800-1900)
Systemic WBC Counts	9000 (4000-14000)	2100 (1100-2600)^a	3400 (2200-4600)

^aP < 0.05 vs control and 5-FU + G-CSF groups.

Citation: Cerci C, Ergin C, Eroglu E, Agalar C, Agalar F, Cerci S, Bulbul M. Effects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in rats. World J Gastroenterol 2007; 13(18): 2596-2599
URL: https://www.wjgnet.com/1007-9327/full/v13/i18/2596.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i18.2596