Genetic diversity of the hepatitis C virus: Impact and issues in the antiviral therapy

Figure 5 Three-dimensional structure of NS5B RNA-dependent RNA polymerase (PDB accession code 1QUV). The three subdomains of the polymerase are shown (Fingers, Thumb and Palm) as well as the main residues targeted by each class of polymerase inhibitors (NNI 1: Non nucleoside class 1, NNI 2: Non nucleoside class 2, NNI 3: Non nucleoside class 3, NI: Nucleoside Inhibitor). This figure was prepared using the RasTop programme version 2.0.3-VF.