Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptor-1-mediated anti-angiogenesis and low-dose gemcitabine in a mouse colon adenocarcinoma model

Table 1 Synergistic indexes of combination therapy relative fraction¹

Day2	FGFR-1	Gemcitabine	Combination therapy		Index4
			Expected3	Observed
Tumor volume index	0.48	0.60	0.29	0.17	1.71
MVD index	0.35	0.66	0.23	0.20	1.15
Apoptosis index	0.48	0.43	0.21	0.19	1.11
Proliferation index	0.49	0.46	0.22	0.21	1.04

¹Relative Fraction (RF) = mean tumor volume (or MVD, apoptosis and proliferation index) experimental/mean tumor volume (or MVD, apoptosis and proliferation index) untreated on d 31, respectively. –²Day after tumor cell transplantation. –³RF of gemcitabine × RF of cFR-1 vaccine. –⁴Obtained by dividing the expected RF by the observed RF.