Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats

Figure 6 Effects of the SC-236 on pancreatic inflammatory changes following AP. A: Representative HE-stained sections of pancreas in control rats not given CCK-octapeptide (left panel), in rats given CCK-octapeptide (middle panel), and in rats given SC-236 (right panel). Original magnification × 200; B: Histologic sections of pancreata harvested 12 h after injections of saline (CON), CCK-octapeptide alone, or SC-236-treated groups were scored from 0 (normal) to 3 (severe) for edema, inflammation, vacuolization, and necrosis as described in Materials and Methods. aP < 0.05 vs the saline-treated group.