Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats

Figure 4 SC-236 inhibits NF-κB activation in CCK-octapeptide-induced AP. Protein extracts were prepared from pancreas harvested at 3 h after last injection into animals with DMSO, CCK-octapeptide, or SC-236 with CCK-octapeptide. Extracts were assayed for NF-κB binding activity by EMSA as described in the Materials and Methods.