Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production

Figure 8 IL-12 production by the colonic mucosa. Levels of IL-12 are measured in supernatants of organ cultures and presented as pg/μg of tissue protein, in the groups: untreated colitis, therapeutic- and prophylactic-thalidomide, placebo-treated, and normal controls, respectively (n = 10 in each group). Horizontal bars represent medians, boxes represent the 25^th and 75^th percentiles, and vertical bars represent ranges. Differences were analysed using one-way ANOVA with the Dunnett’s test for multiple comparisons. Significant differences are presented.