In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes

Table 3 Cell viability, LDH activity and concentrations of TBARS and GSH after 1 h incubation with 14 μmol/L amiodarone, 10 μmol/L lovastatin and 86 μmol/L CCl₄ (mean ± SD)

Group	Cellviability%	LDHnmol/min/106cells	TBARSnmol/106cells	GSHnmol/106cells
Control	75 ± 5.97	0.157 ± 0.096	0.102 ± 0.018	13.0 ± 2.53
86 μmol/L CCl4	35 ± 6.59j	0.563 ± 0.098j	0.304 ± 0.056j	1.24 ± 0.43j
10 μmol/L Lovastatin	41 ± 2.36j	0.336 ± 0.007f	0.194 ± 0.022j	2.05 ± 0.042h
10 μmol/L Lovastatin + 86 μmol/L CCl4	45 ± 1.52bj	0.239 ± 0.016a	0.130 ± 0.041af	7.50 ± 0.008d
14 μmol/L amiodarone	65 ± 2.71dj	0.229 ± 0.046b	0.156 ± 0.072ah	5.51 ± 1.06fj
14 μmol/L amiodarone + 86 μmol/L CCl4	39 ± 6.63j	0.270 ± 0.032af	0.162 ± 0.059ah	4.80 ± 0.284dj
14 μmol/L amiodarone + 10 μmol/L lovastatin	52 ± 4.58dfj	0.294 ± 0.032hl	0.166 ± 0.063ah	5.42 ± 1.04bjl
14 μmol/L amiodarone + 10 μmol/L lovastatin + 86 μmol/L CCl4	35 ± 2.22j	0.286 ± 0.052f	0.151 ± 0.077af	2.94 ± 1.61j

^aP < 0.05 vs CCl₄ group;

^bP < 0.01 vs CCl₄ group;

^dP < 0.001 vs CCl₄ group;

^fP < 0.01 vs control;

^hP < 0.01 vs control;

^jP < 0.01 vs control;

^lP < 0.01 vs lovastatin group.