In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes

Table 2 Cell viability, LDH activity and concentrations of TBARS and GSH after 1 h incubation with different concentrations lovastatin and 86 μmol/L CCl₄ (mean ± SD)

Group	Cell viability(%)	LDH nmol/min/106 cells	TBARS nmol/106 cells	GSHnmol/106 cells
Control	75 ± 5.97	0.157 ± 0.096	0.102 ± 0.018	13.0 ± 2.53
CCl4	35 ± 6.59f	0.563 ± 0.098f	0.304 ± 0.056f	1.24 ± 0.43f
1 μmol/L Lovastatin + CCl4	33 ± 4.99f	0.342 ± 0.028da	0.193 ± 0.004da	1.40 ± 0.49f
3 μmol/L Lovastatin + CCl4	42 ± 4.50d	0.328 ± 0.041a	0.170 ± 0.020a	2.49 ± 0.10f
5 μmol/L Lovastatin + CCl4	43 ± 7.77d	0.291 ± 0.025a	0.160 ± 0.014a	6.55 ± 0.005fb
10 μmol/L Lovastatin + CCl4	45 ± 1.52d	0.239 ± 0.016a	0.130 ± 0.041a	7.50 ± 0.008db

^aP < 0.05 vs CCl₄ group;

^bP < 0.01 vs CCl₄ group;

^dP < 0.01 vs control;

^fP < 0.001 vs control.