In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes

Table 1 Cell viability, LDH activity and concentrations of TBARS and GSH after 1 h incubation with lovastatin (mean ± SD)

Groups	Cell viability %	LDH nmol/min/106 cells	TBARSnmol/106 cells	GSH nmol/106 cells
Control	75 ± 5.97	0.157 ± 0.096	0.102 ± 0.018	13.0 ± 2.53
1 μmol/L Lovastatin	68 ± 0.051b	0.214 ± 0.084	0.138 ± 0.061	9.63 ± 1.19
3 μmol/L Lovastatin	52 ± 4.28d	0.248 ± 0.063b	0.158 ± 0.016b	4.68 ± 1.06b
5 μmol/L Lovastatin	48 ± 9.19d	0.272 ± 0.057b	0.169 ± 0.067b	3.93 ± 0.51b
10 μmol/L Lovastatin	41 ± 2.36d	0.336 ± 0.007b	0.194 ± 0.022d	2.05 ± 0.042d

^bP < 0.01 vs control;

^dP < 0.001 vs control.