Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful?

Figure 1 Some of the principal tumor targets of polyphenols discussed in the text. The agents may directly interfere with the affected molecules (e.g. Telomerase, COX-2 and P-gp) and/or influence their activity or expression due to modifications in an upstream regulatory signal or in factors (e.g. NF-κB) which regulate gene transcription.