Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents

doi:10.3748/wjg.v13.i14.2053

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Apr 14, 2007 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2007; 13(14): 2053-2060
Published online Apr 14, 2007. doi: 10.3748/wjg.v13.i14.2053

Table 6 Changes in the concentrations of nonprotein and protein sulfhydryls and disulfides in the rat glandular stomach in the early phase of chemically-induced mucosal injury

Agent	Total GSH	GSSG	GSH/GSSG	PSH	PSSG	PSSP	PSH/PSSG	SH/PSSP
Ethanol	DD	II	DD	DD	III	III	DD	DD
HCl	D	I	DD	D	No	II	No	DD
NaOH	DD	No	D	No	I	I	DD	DD
NaCl	No	No	D	D	No	I	DD	D
Ammonia	No	I	D	No	No	No	No	D

Total GSH: GSH + GSSG; GSSG: glutathione disulfide; PSH: protein SH; PSSG: protein-GSH mixed disulfide; PSSP: protein disulfides; I: increase; D: decrease, Ior D: P < 0.05; II or DD: P < 0.01; III or DDD: P < 0.001; No: no significant change in comparison with corresponding controls in the 12 min experiments.

Citation: Nagy L, Nagata M, Szabo S. Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents. World J Gastroenterol 2007; 13(14): 2053-2060
URL: https://www.wjgnet.com/1007-9327/full/v13/i14/2053.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i14.2053