A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 9 HLA association with response to interferon therapy in chronic hepatitis (B and C) patients across global population

HLA	Effect	Country	R	NR	References
Hepatitis B
HLA DQA1*0501 and DQB1*0301	Responsiveness	China	32	28	[85]
HLA-DRB1*14	Responsiveness	China	11	24	[14]
HLA DRB1*04,DQA1*0303	Non-responsiveness	China	32	28	[85]
HLA-DRB1*07 (HBV type c)	Non-responsiveness	China	7		[152]
HLA-DQB1*07	Low response	China	11	24	[14]
Hepatitis C
Non responsiveness
HLAIHLA B54	Non responsiveness	Japan	20	47	[86]
HLAII, HLA DR9	Non responsiveness	Japan			[153]
HLA DR6	Non responsiveness	Japan	21	32	[154]
HLA DRB1*04 (males and HCV1b)	Non responsiveness	China	10	11	[84]
HLA B1*13	Non responsiveness	Turkey			[155]
DRB1*07	Non responsiveness	France	50	120	[75]
Responsiveness
HLAIHLA B55, B62 and Cw3	Responsiveness	Japan	54	118	[156]
HLA B51, CW1	Responsiveness	Japan			[153]
HLA B44	Responsiveness to Interfron + Ribavirin	Spain	53	52	[87]
HLAII HLA DRB*10101	Responsiveness	Japan	32	106	[157]
HLA DR6	Responsiveness	Japan	21	32	[154]
HLA DRB1*07 (females and HCV 2b)	Responsiveness	China	10	11	[84]
HLA DR2	Responsiveness	Egypt	25	30	[158]
DQB1*06(HCV genotype 1)	Responsiveness	France	50	120	[75]
HLA DRB1*0404	Responsiveness	Canada	6	64	[88]
Haplotypes
HLA A-24-B54-DR4	Non responsiveness	Japan	20	47	[86]
HLA B7-DRB10101	Responsiveness	Japan	32	106	[157]
DRB1*0701-DQA1*0201-DQB1*02	Responsiveness	Poland	29	26	[108]