Review
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 28, 2007; 13(12): 1770-1787
Published online Mar 28, 2007. doi: 10.3748/wjg.v13.i12.1770
Table 7 Association of HLA alleles with Protection from HCV infection and viral clearance
HLA IEffectCountryNCRChronic infection
Reference
ACCHC/CLD
HLAIHLA-B51, -B52, B61, -Cw1, Cw3, and Cw4VCJapan172113[59]
HLA A2ACJapan172113[59]
B50 (21)VCEgypt[55]
HLA-B8,Protection from infectionSaudi people122146[54]
HLA-Cw4Protection from chronic infectionRussia[5]
HLA A*03,B*07,B*27,Cw*01VC/Protection from chronic infectionIreland86141[60]
HLA-A*1101,HLA-B*57 and HLA-Cw*0102Viral clearanceUSA231444[58]
HLA-Cw*0602Protection against vertical infectionItaly (infants born to HCV+ ve mothers)44 uninfected infants born to HCV+ mothers21[16]
HLA Bw4180/KIR3DS1HCV carriersSpain1165147 (LC), 54 (HCC)[64]
HLA-C1/KIR2DL3VC/protection from infectionUK352685[62]
HLA A*34,B*56Low viral loadTaiwan[142]
HLA II HLA-DR9- DQB1*0301 and DQB1*0303VC/protection from HCV infectionJapan29360[69]
HLA DRB1*1302, DRB1*1101## and DQB1*0604 allelesAC/no CLDJapan9163397[68]
HLA DRB1*12(1201/1202), DQBI*0301, DRB3*03AC/no CLDJapan2014360[132]
HLA DRB1*0901,DQB1*0303AC-no LCJapan12165067[70]
HLA DRB1*04, DRB1*0701, DQA1*0201,DQB1*0301VCThailand140432136[133]
HLA DRB1*0301, DQA1*0501 and DQB1*0201VC/protection from HCV infectionKorea206137[109]
HLA DRB1*0101##VCEgypt (Hemophilic and HCV- HCC+ ve patients)15 Healthy & 25 HCV-10 HCV+15 HCV- HCC+[134]
HLA DRI and DR3VC/Protection from infectionSaudi people122146[54]
HLA DRB1*11#VC/Protection from infectionTurkey4349[143]
HLA DQA1*03 and DQB1*0302VC/Protection from chronic infectionN.European whites177104[144]
HLA-DRB1*0301,DRB1*1101#, DRB1*1201# and HLA-DQB1*0301Viral clearanceUK (European)85170[135]
HLA DRB1*04, DQA1*03 and DQB1*0301VC/Protection from chronic infectionUK1344955[145]
HLA DQB1*0302Protection from infectionUK1344955[145]
HLA DRB1*01##. (HCV 1b)VCIreland (females who received HCV 1b contaminated AntiD immunoglobulin)8472[136]
HLA DRB1*0101##, DRB1*0401, DRB1*15VC/Protection from chronic infectionIreland86141[60]
HLA DRB1*0101##Viral clearanceIreland7384[78, 146]
HLA DR5#Protection from chronic hepatitis CItaly489117[130]
HLA II HLA DRB1*1601, DQB1*0502Protection from HCV infectionSardinia (Thalassemia major for transfusion)606 healthy & 30 HCV- patients116[147]
HLA DRB1*1104, and DRB3*03Protection from chronic manifestation /carriesItaly1794199[137]
HLA DRB1*1104,DQB1*0301VCItaly2003542107[138]
HLA DR 11VC/Protection from infectionItaly703429[139]
HLA DQB1*0301Protection from HCV related HCCItaly14429[148]
HLA DRB1*1301 and DQA1*0103Protection from chronic HCV infectionGermany101105[140]
HLA-DRB1*15011Viral clearance/ ProtectionGermany2149[149]
HLA-DRB1*11(DR5) and HLA-DQB1*03(DQ3)Protection from CLDGermany501108[150]
HLA-DR11AC/Protection from CLDSpain1164893[131]
HLA DQB1*0301Protection from chronic infectionPoland103129[108]
HLA DRB1*11Mild liver damagePoland134[95]
HLA DQB1*0301 and DRB1*1101VCFrance80025103[74]
HLA DQB1*0301 and female sexVCFrance80063282[75]
HLA DRB1*11Protection from progression of liver diseaseFrance233[141]
HLA DRB1*11 (female association)AC/less severity of chronic hepatitisFrance83233[76]
HLA DQB1*0301VC (strongly in Black subjects)USA200374[77]
HLA DRB1*0101, DQB1*0501VC (in white subjects)USA200374[77]
HLA DR13Protection against vertical infectionItaly (infants born to HCV+ ve mothers)17 (serum reverted)18[17]
HLA-DQB1*06, -G*0105N, DRB1*1104 and -DRB1*1302 allelesProtection against vertical infectionItaly (infants born to HCV+ ve mothers)44 uninfected infants born to HCV+ mothers21[16]
HLA DRB1*1502Low viral loadTaiwan[142]
VC: Viral clearance; CHC: Chronic hepatitis C; CLD: Chronic liver disease; NC: Normal control; R: Recovered; LC: Liver cirrhosis; AC: Asymptomatic carriers. Common HLA alleles #: DR5 (DRB1*11, DRB1*12 allele), ##: DRB1*0101, DQB1*0301.