A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 6 Association of HLA alleles with susceptibility to viral persistence &chronic HCV infection across global population

HLA	Effect	Country	NC	R	Chronicinfection		Reference
					AC	CLD/CHC
HLAIHLA-B61, Cw3,	VP/HCV infection	Japan	293			60	[69]
HLA B54	VP with CLD	Japan	916		33	97	[68]
HLA B55, -B56, B70	VP	Japan	172			113	[59]
HLA A3, B-35, B-46	VP	Korea	206			137	[109]
HLA A28, A29, B14	HCV infection	Egypt					[55]
HLA A-19	HCV infection	Saudi people.	122			146	[54]
HLA-A10, HLA-B35, HLA-B40 and HLA-Cw3	VP-CLD	Russia					[5]
HLA-A30, B35, B41, Cw2, A1-B35, A9-B8	VP-CLD-LC	Russia				107	[57]
HLA B8, B18	VP-CHC	Ireland		86		141	[60]
HLA C*04	VP	Ireland (Whites)		86		139	[56]
HLA B14	VP & active hepatitis C	Italy	489			117	[130]
HLA B18	Susceptibility to CLD	Spain	116		48	93	[131]
HLA-A*2301 and HLA-Cw*04	VP	USA		231		444	[58]
HLA-Cw*07,	Risk factor for vertical infection	Italy (infants born to HCV+ mothers)	44 uninfected infants born to HCV+ mothers			21	[16]
HLA II HLA DR4, DQB1*0401 DQB1*0402	VP/ HCV infection	Japan	293			60	[69]
HLA DRB1*0405, DQB1*0401	VP with CLD	Japan	916		33	97	[68]
HLA DRB1*0405, DQB1*0401	VP with LC	Japan	1216		50	67	[70]
HLA DQB1*0503	VP with LC	Japan	201		43	60	[132]
HLA DRB1*0301#, DQB1*0201, DQB1*0502	VP/CHC	Thailand	140	43	21	36	[133]
HLA, DRB1*0803, DQB1*0601 and DQB1*0604	VP	Korea	206			137	[109]
HLA DRB1*0301#	VP	Egypt (Hemophilic and HCV-, HCC+ patients)	15 Healthy & 25 HCV-		10 HCV+	15 (HCV- HCC+)	[134]
HLA DR7	HCV infection	Egypt					[55]
HLA-DRB1*0701, DRB1*15, DRB4*0101	Viral persistence	UK (European)		85		170	[135]
HLA DQB1*0201	VP-CHC	Ireland		86		141	[60]
HLA DRB1*0701 (HCV 1b)	VP	Ireland (females receiving HCV 1b contaminated AntiD immunoglobulin)		84		72	[136]
HLA DRB1*1001, DRB1*1101	VP/CLD	Italy	179		41	99	[137]
HLA DQB1*0502	VP-CLD	Italy	200	35	42	107	[138]
HLA DR14, DR17	VP-CLD	Italy	70		34	39	[139]
HLA DRB1*0301	VP-CHC	Germany	101			105	[140]
HLA DRB1*07	VP-CLD	German & North Europeans	2045			99	[94]
HLA DR B1*13 and DRB1*14	Susceptibility to infection	German & North Europeans	2045			99	[94]
HLA DR3#	Susceptibility to chronic disease	Spain	116		48	93	[131]
HLA DRB1*13 and DRB1*07	Necro inflammatory activity during infection	Poland				134	[95]
HLA DRB1*13 allele	VP	Poland				134	[95]
DRB1*03# and DQB1*0201(male gender)	CLD/LC	France				233	[141]
HLA G*010401, -DRB1*0701, -DRB1*1401 and homozygosity for HLA-G 14bp deletion	Risk factor for vertical infection	Italy(infants born to HCV+ mothers)	44 uninfected infants born to HCV+ mothers			21	[16]
HLA DRB*4001	High viral load	Taiwan					[142]
HLA III MICA-A4	Susceptibility to CLD	Spain	116		48	93	[131]

VP: Viral persistence/chronic infection; CHC: Chronic hepatitis C; CLD: Chronic liver disease; NC: Normal control; R: Recovered; AC: Asymptomatic carriers; LC: Liver cirrhosis. Common VP alleles: # DRB1*03, DRB1*0701.