A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 4 HLA association with responsiveness to HBsAg vaccine across global population

HLA	Effect	Country	Vaccinees	Rs	NRs	Reference
HLAI, HLA A1, B7, B12	Responsiveness (Low)	Germany Poland	ESRD Patients on hemodialysis	119	34	[46]
HLA A1, A19, B5, B27, Cw2, Cw4	Responsiveness (High)	Germany Poland	ESRD Patients on hemodialysis	119	34	[46]
HLA II, HLA DRB1*02	Responsive	China (Han)	Healthy vaccinees	145	118	[122]
HLA DRB1*0101, DRB1*08032, DQA1, DQB1, DPA1 and DPB1	Responsiveness	Japan	Healthy medical students			[35]
HLA DR4	Responsiveness (Low)	Germany, Poland	ESRD Patients on hemodialysis	119	34	[46]
HLA DRB1*010, DR5, DPB1*040, DQB1*0301, DQB1*0501.	Responsiveness	Belgium	Vaccinees	134	117	[39]
HLA DRB1*01, *DRB1*15# and DRB1*16	Responsiveness	France	Hemodialysis patients	301	114	[124]
HLA DRB1*1301, *DR15#, DQA1*0103, DQA1*0102, DQB1*0603,	Responsiveness	Sweden	Healthy vaccinees	69	53	[48]
HLA DRB1*11, DQB1*0301	Responsiveness	Italy	Neonates	76	49LR, 43SR 19TNR	[34]
HLA DRB1*1 DRB1*13, *DRB1*15#	Responsiveness	Germany	Healthy adults & infant vaccinees	109	135	[127]
HLA III C4A*6, C4B*2, Bf*F	Responsiveness (High)	Germany Poland	ESRD Patients on hemodialysis	119	34	[46]

Rs: Responders; NRs: Non-responders, ESRD: End stage Renal Disease, LR: Low responders, SR: Slow responders, TNR-total non-responders common HLA alleles: DRB1*01, #: DR15.