A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 3 HLA allele association with Non-responsiveness to HBsAg vaccine across global population

HLA	Effect	Country	Vaccinees	Rs	NRs	Reference
HLAIHLA B54	Non- responsiveness	China	Healthy vaccinees	30	29	[118]
HLA A*0602, A*1101 and B*35	Non-responsiveness/ antibody production	Japan	Healthy medical students			[35]
HLA A1, A10, B15, B40.	Non responsiveness	India	Healthy volunteers	15 of 87 Rs	15	[37]
HLA A10, CW4	Non-responsiveness	Turkey	Health care workers		12	[119]
HLA A1, B8	Non-responsiveness	Germany, Poland	ESRD Patients on hemodialysis	119	34	[44,46]
HLA B8	Non-responsiveness	Belgium	Homosexual vaccinees	39	9	[120]
HLA A2	Non-responsiveness	Spain	Hemodialysis patients			[121]
HLA II HLA DR7##	Non- responsiveness	China	Healthy vaccinees	30	29	[118]
HLA DRB1*07##	Non-responsiveness	China (Han)	Healthy vaccinees	145	118	[122]
HLA DR14, DR52	Non- responsiveness	Chinese (Taiwan)	Non responder vaccinees		26	[123]
HLA DRB1*0405, DRB1*1101, DR4	Non-responsiveness/ antibody production	Japan	Healthy medical students			[35]
HLA DQ2$	Non responsiveness	India	Healthy volunteers	15 of 87	15	[37]
HLA DR7#	Non-responsiveness	Turkey	Health care workers		12	[119]
HLA DR3, DQ2$	Non-responsiveness	Germany, Poland	ESRD Patients on hemodialysis	119	34	[44,46]
HLA DR3	Non-responsiveness	Belgium	Homosexual vaccinees	39	9	[120]
HLA DRB1*07#, *DQB1*02$, and DPB1*1101	Non-responsiveness	Belgium	Vaccinees	134	117	[39]
HLA DRB1*03, DRB1*14	Non-responsiveness	France	Hemodialysis patients	301	114	[124]
HLA DRB1*1302, DQB1*0604, DQA1*0102	Non-responsiveness	Sweden	Healthy vaccinees	69	53	[48]
HLA DRB1*0701#, DQB1*0202$	Non-responsiveness	UK	Vaccinees	117	86	[125]
HLA DRB1*0701#, DQB1*0202$	Non-responsiveness	UK	HBsAg Non responders			[45]
HLA DQB1*02$	Non-responsiveness	Italy	Neonates	76	49LR, 43SR 19TNR	[34]
HLA DRB1*1601, DQB1*0502, DQA1*0102 Haplotype	Non-responsiveness	Slovenia	Health care workers	60	36	[126]
HLA DR3, DR7#, DQ2$	Non-responsiveness	Spain	Hemodialysis patients			[121]
HLA DRB1*3, DRB1*7, DRB1*14x	Non-responsiveness	Germany	Healthy adults & Infant vaccinees	53 & 56	73 & 62	[127]
HLA-B8, SC01, DR3 and HLA B44-FC31, DR7#	Non-responsiveness	USA	Healthcare worker		20	[33,49]
HLA DRB1*07#	Non-responsiveness	USA	Healthy vaccinees	85	79	[128]
HLA III HLA C4A*6, C4A*Q0##, Bf*F, Bf*S07	Non-responsiveness	Germany, Poland	ESRD Patients on hemodialysis	119	34	[46]
HLA C4AQ0##	Non-responsiveness	Italy	Neonates	40	26LR, 21SR, 10TNR	[41]
HLA C4AQ0##	Non-responsiveness	Italy	Neonates	76	49LR, 43SR 19TNR	[34]
HLA C4AQ0##	Non-responsiveness	Germany	Healthy vaccinees	53	73	[42]

Rs: Responders; NRs: Non-responders; ESRD: End stage renal disease; LR: Low responders, SR: Slow responders; TNR: Total non-responders. Common HLA alleles $: DQ2, #: DR7, ##: C4AQ0, DR3.