A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 2 Association of HLA allele with protection from chronic HBV infection across global population

HLA	Effect	Country and cases	NC	R	CI	Reference
HLAIHLA B61	Early HBeAg seroconversion	Taiwan (chronically infected children)			81	[114]
HLA A*26	No disease progression in HBV carriers	Japan				[8]
HLA A-24 and Cw1	Low risk for HBV related chronic disease	Turkey	50		50	[9]
HLA A2	VC	Russia				[5]
HLA A11	VC	Kazakh				[5]
HLA A*0301	VC	USA (Caucasians)		342	194	[7]
HLA II
HLA DRB1*4001	VC	Taiwan (Taiwanese Aborigines)	98	324	98	[4]
HLA DRB1*0406, DRB1*0701	VC	Taiwan (Han Chinese)	98	324	98	[4]
HLA DQA1*0301, DQA1*0102	VC/AC	China		148 (R) & 212 (AC)	207	[113]
HLA DRB1*1101/ *1104, DQA1*0301	VC	China	106	30	54	[10]
HLA DR12 (DRB1*1201)	VC	China		56	30	[11]
HLA-DRB1*07	VC/Protection from HBV infection.	China	200		72	[14]
HLA DR6 (DRB1*13)	VC	Korea (ESRD patients)	946	243	83	[19]
HLA DRB1*13	VC	India	100		26	[12]
HLA DRB1*1301 and DRB1*1302	VC	Gambia (children & Adult men)	891 & 25	218 & 195	185 & 40	[110]
HLA DRB1*1301/1302	VC	Spain	24	11	38	[115]
HLA DRB1*1301/1302	VC	Germany	101		117	[116]
HLA DR13 (DRB1*13)	VC	Germany	208	33	32	[117]
HLA DQB1*0503	Early HBeAg seroconversion	Taiwan (Chronically infected children)			81	[114]
HLA DR13	Resistance to HBV infection & vertical transmission	China (Pregnant women)	40		78	[15]
HLA-DRB1*1501/1502	Protection from liver cirrhosis	China (Cirrhosis subjects from Hubei area)	108		116	[13]
HLA DR5	No disease progression in HBV carriers	Japan				[8]

VC: Viral clearance/self limiting infection, AC: Asymptomatic carriers; Common VC alleles: DRB1*13; ESRD: End Stage Renal Disease; R: Recovered; HBV:Hepatitis B virus