A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 1 Association of HLA alleles with Chronic HBV infection across global population

HLA	Effect	Country and cases	Healthy controls	Recovered	Chronic infection	Reference
HLAI
HLA A*0206	VP	Taiwan (Taiwanese borigines)	34	229	138	[4]
HLA B-35	VP	Taiwan (Han Chinese)	98	324	98	[4]
HLA A*2	VP/Disease severity	Japan				[8]
HLA B18, B35, B40, Cw3	Susceptibility to chronic HBV infection	Russia				[5]
HLA A3, B18	Susceptibility to chronic HBV infection	Kazakh				[5]
HLA: B8-Cw7 haplotype	Liver cancer associated with HBV infection	Senegal	96		98	[6]
HLA B*8	VP	USA (Caucasians)		342	194	[7]
HLA A*01-B*08-DRB1*03, B*44-Cw*1601 and B*44-Cw*0501 haplotype	VP	USA (Caucasians)		342	194	[7]
HLA II
HLA DRB1*1202#	VP	Taiwan (Han Chinese)	98	324	98	[4]
HLA DQA1*0302	VP	China		148 (R), 212 (AC)	207	[113]
HLA DRB1*0301, DQA1*0501, DQB1*0301	VP	China	106	30	54	[10]
HLA DR9, DQ9	VP	China		56	30	[11]
HLA-DRB1*06, DRB1*08, and DRB1*16	VP	China	200		72	[14]
HLA DR9	VP	Korea (ESRD patients)	946	243	83	[19]
HLA DRB1*11# and DRB1*15	VP	India	100		26	[12]
HLA DQA1 *0501, DQB1 *0301	VP	USA (African American)		60	31	[18]
HLA DR3	Susceptibility to HBV infection & vertical transmission	China (Pregnant women)	40		78	[15]
HLA-DRB1*1201/1202#	Susceptibility to liver cirrhosis	China (Cirrhosis subjects from Hubei area)	108		116	[13]
HLA B13, B8, DR7, DR13, DQ3	Susceptibility to chronic HBV infection	Turkey	50		50	[9]
HLA DQA1 0501, DQB1 0301, DRB1 1102# haplotype	VP	USA (African American)		60	31	[18]

VP: viral persistence/chronic infection; AC: Asymptomatic carriers; Common VP alleles: DQB1*0301, #: DRB1*11/12; ESRD: End stage renal disease; R: Recovered; HBV Hepatitis B virus.