Upregulation of hypoxia inducible factor 1α mRNA is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinoma

Figure 3 Relationship between HIF-1α mRNA, VEGF protein, MVD and prognosis. A: Survival curves by the Kaplan-Meier method. Log-rank test revealing a significant difference between negative and positive expression of HIF-1α mRNA (P < 0.05); B: Survival curves based on the Kaplan-Meier method. Log-rank test revealing a significant difference between negative and positive expression of VEGF (P < 0.05); C: Survival curves by the Kaplan-Meier method. There was a significant difference in Log-rant test between patients with MVD value < 41.5/0.72 mm² and those with MVD value ≥ 41.5/0.72 mm².