Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines

Figure 4 A: Effect of UDCA on expression of bcl-2 in BEL7402, immuno-cytochemical staining of bcl-2. The accumulation of bcl-2 protein is indicated by a brown coloration in the cytoplasm (× 200). Control group, expression of bcl-2 in BEL7402 cultivated for 48 h (Left), Expression of bcl-2 in BEL7402 treated with UDCA (0.4 mmol/L) for 48 h (Right); B: Effect of UDCA on expression of Bax in BEL7402, immunocytochemical staining of Bax. The accumulation of Bax protein is indicated by a brown coloration in the cytoplasm. Control group,expression of Bax in BEL7402 cultivated for 48 h (Left). Expression of Bax in BEL7402 treated with UDCA (0.4 mmol/L) 48 h (× 200) (Right).