Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines

Figure 3 Morphology of HepG2 treated with UDCA (0. 4 mmol/L) for 48 h (TEM, × 4000). A: Nuclear frag-mentation,chromosome condensation, cell shrinkage and loss of cell-cell contact are visible; B: Subsequent ruffling and blebbling of the cell membrane, and formation of apoptotic bodies are also observed.