Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohepatitis in rats

Table 2 Change of hepatic function and intestinal permeability in rats

Time(wk)	Group	Number	ALT (mmol/L)	AST (mmol/L)	ALB (g/L)	D-lactate(mmol/L)	DAO (U/L)
8	Control	12	54.75 ± 7.05	200.33 ± 14.49	30.39 ± 2.33	0.19 ± 0.04	0.74 ± 0.11
	Model	12	125.75 ± 34.21a	270.91 ± 45.38d	26.91 ± 2.37g	0.36 ± 0.11h	0.77 ± 0.09
12	Control	11	56.73 ± 8.46	215.64 ± 31.53	31.09 ± 1.30	0.17 ± 0.03	0.65 ± 0.15
	Model	6	149.67 ± 30.81b	311.33 ± 53.33e	29.83 ± 1.72	0.54 ± 0.04i	0.92 ± 0.10k
16	Control	11	51.59 ± 7.54	195.10 ± 18.72	29.12 ± 2.51	0.20 ± 0.05	0.77 ± 0.17
	Model	9	166.56 ± 43.53c	314.22 ± 54.41f	28.98 ± 2.10	0.86 ± 0.12j	1.28 ± 0.19l

Values are expressed as mean ± SD. a: t = 7.04, P < 0.001, vs control group at the 8^th wk; b: t = 7.24, P < 0.001, vs control group at the 12^th wk; c: t = 7.83, P < 0.001, vs control group at the 16^th wk; d: t = 5.13, P < 0.001, vs control group at the 8^th wk; e: t = 4.70, P < 0.001, vs control group at the 12^th wk; f: t = 6.82, P < 0.001, vs control group at the 16^th wk; g: t = 5.24, P < 0.001, vs control group at the 8^th wk.; h: t = 5.50, P < 0.001, vs control group at the 8^th wk ; i: t = 9.70, P < 0.001, vs control group at the 12^th wk; j: t = 7.22, P < 0.001, vs control group at the 16^th wk; k: t = 3.91, P = 0.001, vs control group at the 12^th wk; l: t = 6.27, P < 0.001, vs control group at the 16^th wk.