Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohepatitis in rats

Table 1 Change of body, hepatic and serum lipid parameters in rats

Time(wk)	Group	Number	Weight	Hepaticindex (%)	TG (mmol/L)	TCh (mmol/L)	Degree of HepaticSteatosis				HAI mark
							-	+	++	+++
8	Control	12	307.58 ± 17.04	2.64 ± 0.09	0.51 ± 0.07	1.62 ± 0.16	12	0	0	0	0.67 ± 0.33
	Model	12	404.50 ± 13.18a	3.88 ± 0.53a	0.35 ± 0.05b	2.49 ± 0.36c	0	3	6	3	0.68 ± 0.27
12	Control	11	411.05 ± 16.84	2.81 ± 0.09	0.48 ± 0.10	1.38 ± 0.24	11	0	0	0	0.71 ± 0.12
	Model	6	506.16 ± 15.99a	4.58 ± 0.07a	0.49 ± 0.10	6.20 ± 2.14d,e,f	0	0	2	4	3.95 ± 0.83h,i
16	Control	11	453.55 ± 49.11	2.77 ± 0.12	0.51 ± 0.07	1.96 ± 0.45	11	0	0	0	0.69 ± 0.15
	Model	9	554.22 ± 28.37a	4.74 ± 0.13a	0.47 ± 0.10	2.93 ± 0.55g	0	0	1	9	5.25 ± 1.39h,j

Values are expressed as mean ± SD. a: P < 0.001 vs corresponding control group; b: t = 6.31, P < 0.001, vs control group at the 8^th wk; c: t = 7.67, P < 0.001, vs control group at the 8^th wk; d: t = 5.49, P = 0.003, vs control group at the 12^th wk; e: t = 3.60, P = 0.012, vs model group at the 16^th wk; f: t = 4.21, P = 0.008, vs model group at the 8^th wk; g: t = 3.53, P = 0.002, vs control group at the 16^th wk; h: P < 0.05, vs control group at the same stage of time; i: P < 0.05, vs model group at the 8^th wk; j: P < 0.05, vs model group at the 12^th wk.